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Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 290-303 doi: 10.1007/s11684-022-0956-8

Abstract: Esophageal squamous cell carcinoma (ESCC) is one of the leading causes of cancer death worldwide.

Keywords： benzydamine     cyclin-dependent kinase 2     patient-derived xenograft     esophageal squamous cell carcinoma    

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Molecular alterations and clinical relevance in esophageal squamous cell carcinoma

Li Shang, Mingrong Wang

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 401-410 doi: 10.1007/s11684-013-0286-y

Abstract:

Esophageal squamous cell carcinoma (ESCC) is one of the most common types of gastrointestinal cancersMolecular classification will be useful for subtyping esophageal tumors or precancerous lesions to improve

Keywords： esophageal squamous cell carcinoma (ESCC)     early detection     molecular classification     molecular markers    

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U-shaped association between telomere length and esophageal squamous cell carcinoma risk: a case-control

Jiangbo Du,Wenjie Xue,Yong Ji,Xun Zhu,Yayun Gu,Meng Zhu,Cheng Wang,Yong Gao,Juncheng Dai,Hongxia Ma,Yue Jiang,Jiaping Chen,Zhibin Hu,Guangfu Jin,Hongbing Shen

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 478-486 doi: 10.1007/s11684-015-0420-0

Abstract: differences of telomere length could affect predisposition to multiple cancers, but evidence regarding esophagealsquamous cell carcinoma (ESCC) was still uncertain.

Keywords： esophageal squamous cell carcinoma     telomere length     genetic variants     susceptibility     genome-wide association    

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p53 functional activation is independent of its genotype in five esophageal squamous cell carcinoma cell

Junfang JI, Kun WU, Min WU, Qimin ZHAN,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 412-418 doi: 10.1007/s11684-010-0260-x

Abstract: mutations have been found in many esophageal squamous cell carcinoma (ESCC) clinical specimens and cell

Keywords： p53     esophageal squamous cell carcinoma     DNA damage    

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GDF15 negatively regulates chemosensitivity via TGFBR2-AKT pathway-dependent metabolism in esophagealsquamous cell carcinoma

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 119-131 doi: 10.1007/s11684-022-0949-7

Abstract: Treating patients with esophageal squamous cell carcinoma (ESCC) is challenging due to the high chemoresistance

Keywords： GDF15     esophageal squamous cell carcinoma     chemoresistance     cellular metabolism     TGFBR2     AKT    

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Surgical treatment of hepatocellular carcinoma with cirrhotic esophageal varices and hypersplenism: a

JIANG Bin, CHEN Xiaoping, HUANG Zhiyong, ZHANG Zhiwei, HE Songqing, WANG Shaofa, WU Zaide, QIU Fazu

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 24-29 doi: 10.1007/s11684-007-0005-7

Abstract: In treating hepatocellular carcinoma (HCC) patients with advanced cirrhosis, one of the most difficultproblems is concomitant esophageal varices and hypersplenism.To elucidate whether esophageal devascularization or splenectomy is beneficial when simultaneously performedThe results suggest that HCC patients with esophageal varices and hypersplenism should undergo hepaticresection plus esophageal devascularization or splenectomy if radical resection of HCC can be expected
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Clinical response with functional image during radiotherapy of esophageal squamous cell carcinoma

Yu Jinming

Strategic Study of CAE 2012, Volume 14, Issue 7,   Pages 9-19

Abstract:

18F-FLT uptake can be used to monitor the biological response of esophagealbeginning of treatment and estimate clonogenic repopulation during RT. 18F-FETNIM PET can depict hypoxia in esophageal

Keywords： esophageal carcinoma     radiotherapy     positron emission     tomography accelerated repopulation     hypoxia    

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Present status and progress of neoadjuvant chemoradiotherapy for esophageal cancer

Jing Liu, Jinbo Yue, Ligang Xing, Jinming Yu

Frontiers of Medicine 2013, Volume 7, Issue 2,   Pages 172-179 doi: 10.1007/s11684-013-0268-0

Abstract: chemoradiotherapy (nCRT) followed by surgery is gaining popularity as a treatment strategy for locally advanced esophageallonger than non-responders, indicating that pCR is a significant prognostic factor for patients with esophageal

Keywords： esophageal cancer     neoadjuvant     chemoradiotherapy    

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The value of epigenetic markers in esophageal cancer

Xiao-Mei ZHANG, Ming-Zhou GUO,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 378-384 doi: 10.1007/s11684-010-0230-3

Abstract: Developing esophageal cancer is a multi-step process that begins with the accumulation of genetic andIn esophageal cancer, aberrant methylation of promoter regions occurs not only in advanced cancer, butThis review is mainly focused on epigenetic changes in esophageal cancer and the value of early detection

Keywords： epigenetics     DNA methylation     esophageal cancer     dysplasia    

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Potential functions of esophageal cancer-related gene-4 in the cardiovascular system

Rui Zhou, Yuanshu Liu, Wenjun Huang, Xitong Dang

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 639-645 doi: 10.1007/s11684-019-0701-0

Abstract: Esophageal cancer-related gene-4 ( ) is cloned from the normal epithelium of the esophagus.

Keywords： tumor suppressor gene     esophageal cancer-related gene-4     cardiovascular disease     hypoxia    

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Analysis of the treatment outcomes of esophageal variceal bleeding patients from multiple centers in

WANG Zhiqiang

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 171-173 doi: 10.1007/s11684-008-0031-0

Abstract: This study aimed to investigate the treatment outcomes of esophageal variceal bleeding (EVB) in China

Keywords： significant difference     predictive     medication     first-line treatment     bleeding    

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Knockdown of RFC4 inhibits the cell proliferation of nasopharyngeal carcinoma and

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 132-142 doi: 10.1007/s11684-022-0938-x

Abstract: Nasopharyngeal carcinoma (NPC) is a malignant tumor that mainly occurs in East and Southeast Asia.

Keywords： nasopharyngeal carcinoma     WGCNA     RFC4     proliferation    

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The impact of hypoxia in hepatocellular carcinoma metastasis

Carmen Chak-Lui Wong, Alan Ka-Lun Kai, Irene Oi-Lin Ng

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 33-41 doi: 10.1007/s11684-013-0301-3

Abstract:

Hypoxia is a common phenomenon in hepatocellular carcinoma (HCC).

Keywords： hypoxia     hepatocellular carcinoma (HCC)     metastasis     hypoxia-inducible factor (HIF)    

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Esophageal pulse oximetry is more accurate and detects hypoxemia earlier than conventional pulse oximetry

Guo Chen, Zhaoqiong Zhu*, Jin Liu, Wei Wei

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 406-410 doi: 10.1007/s11684-012-0217-3

Abstract: The goal of this study was to evaluate the sensitivity and accuracy of an esophageal pulse oximetry probeAfter tracheal intubation, an esophageal probe was placed in the lower segment of the esophagus for esophageal

Keywords： esophageal pulse oximetry     conventional pulse oximetry     hypoxemia    

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Osteopontin is a promoter for hepatocellular carcinoma metastasis: a summary of 10 years of studies

Lunxiu Qin

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 24-32 doi: 10.1007/s11684-014-0312-8

Abstract: study, OPN was identified as one of the leading genes associated with the metastasis of hepatocellular carcinoma

Keywords： osteopontin (OPN)     hepatocellular carcinoma     metastasis     prognosis     therapeutic target     biomarker     genetic    

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Title Author Date Type Operation

Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma

Journal Article

Molecular alterations and clinical relevance in esophageal squamous cell carcinoma

Li Shang, Mingrong Wang

Journal Article

U-shaped association between telomere length and esophageal squamous cell carcinoma risk: a case-control

Jiangbo Du,Wenjie Xue,Yong Ji,Xun Zhu,Yayun Gu,Meng Zhu,Cheng Wang,Yong Gao,Juncheng Dai,Hongxia Ma,Yue Jiang,Jiaping Chen,Zhibin Hu,Guangfu Jin,Hongbing Shen

Journal Article

p53 functional activation is independent of its genotype in five esophageal squamous cell carcinoma cell

Junfang JI, Kun WU, Min WU, Qimin ZHAN,

Journal Article

GDF15 negatively regulates chemosensitivity via TGFBR2-AKT pathway-dependent metabolism in esophagealsquamous cell carcinoma

Journal Article

Surgical treatment of hepatocellular carcinoma with cirrhotic esophageal varices and hypersplenism: a

JIANG Bin, CHEN Xiaoping, HUANG Zhiyong, ZHANG Zhiwei, HE Songqing, WANG Shaofa, WU Zaide, QIU Fazu

Journal Article

Clinical response with functional image during radiotherapy of esophageal squamous cell carcinoma

Yu Jinming

Journal Article

Present status and progress of neoadjuvant chemoradiotherapy for esophageal cancer

Jing Liu, Jinbo Yue, Ligang Xing, Jinming Yu

Journal Article

The value of epigenetic markers in esophageal cancer

Xiao-Mei ZHANG, Ming-Zhou GUO,

Journal Article

Potential functions of esophageal cancer-related gene-4 in the cardiovascular system

Rui Zhou, Yuanshu Liu, Wenjun Huang, Xitong Dang

Journal Article

Analysis of the treatment outcomes of esophageal variceal bleeding patients from multiple centers in

WANG Zhiqiang

Journal Article

Knockdown of RFC4 inhibits the cell proliferation of nasopharyngeal carcinoma and

Journal Article

The impact of hypoxia in hepatocellular carcinoma metastasis

Carmen Chak-Lui Wong, Alan Ka-Lun Kai, Irene Oi-Lin Ng

Journal Article

Esophageal pulse oximetry is more accurate and detects hypoxemia earlier than conventional pulse oximetry

Guo Chen, Zhaoqiong Zhu*, Jin Liu, Wei Wei

Journal Article

Osteopontin is a promoter for hepatocellular carcinoma metastasis: a summary of 10 years of studies

Lunxiu Qin

Journal Article